The James Simon Gallery is an art gallery located between the reconstructed Neues Museum and the Kupfergraben arm of the Spree river on Museum Island in Berlin, Germany. It was designed by architect David Chipperfield and opened in 2019.

James-Simon-Galerie is the sixth building on Museum Island, the gallery has a prominent position at the site of the former Packhof designed by Karl Friedrich Schinkel, which was demolished in 1938, and its design is inspired by the construction history of Museum Island.